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KMID : 0903520080510030183
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 3 p.183 ~ p.187
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Synthesis and Biological Activities of Aklyl Thiosulfi(o)nates
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Jung Hyun-Jin
Kyung Kyu-Hang
Jung Yi-Sook
Kyung Suk-Hun
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Abstract
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Alkyl thiosulfi(o)nates, analogs of allyl-2-propene-1-thiosulfinate isolated from Allium sativum and having antibacterial activity, were chemically synthesized and their biological activities were investigated. Alkyl thiosulfinates were prepared by oxidation of corresponding disulfides with organic peroxy acid, while alkyl thiosulfonates could be obtained by oxidation of the alkyl thiosulfinates using sodium periodate. All synthetic thiosulfi(o)nates showed antibacterial activity against Staphylococcus aureus B33 and antifungal activitiy against Candida utilis ATCC42416. Further more synthetic alkyl thiosulfonates displayed antioxidant activity and have also prevention effect of platelet aggregation induced by collagen in rat.
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KEYWORD
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Alkyl thiosulfinate, alkyl thiosulfonate, anti-aggregation activity, antibacterial activity, antioxidant, garlic
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